AHCC for Immunity, HPV, COVID-19 and Lyme Illness


In October of 2022, Vitamin Retailer’s sister publication—Pure Practitioner—printed my article, “The Use of AHCC within the Therapy of Human Papillomavirus (HPV).” Within the present article, I’m additionally going to overview the worth of this nutraceutical for HPV, however as well as I’ll be discussing AHCC’s worth for immune operate, COVID-19 and Lyme illness as effectively. Let’s begin with a background overview of AHCC.

AHCC Background

Shiitake (Lentinula edodes) is a mushroom that has been used as a meals and conventional drugs for hundreds of years,1 and is at present used for selling wholesome immune operate,2 wholesome liver function3 and modulating the stomach4 and pancreas most cancers cells,5 and has been validated in scientific literature for these functions. This information was sufficiently promising to encourage one R&D centered nutraceutical firm in Japan to develop a novel shiitake-based compound referred to as AHCC, a singular cultured extract derived from the cell wall of the Shiitake mushroom mycelia, which is wealthy in a number of completely different polysaccharides, together with alpha-glucans and axoglucan fractions, in addition to amino acids, lipids and minerals. Oligosaccharides make up about 74 % of AHCC.6 AHCC is assumed to behave as a organic response modifier and is supported by greater than 30 human medical research and 50-plus papers in PubMed-indexed journals.

AHCC & Immune Perform

AHCC demonstrated early medical promise in selling wholesome immune response.7 This was proven in animal analysis the place AHCC helped restore immune response that had been negatively affected by trauma, an infection and meals deprivation.8 In people, the impact of AHCC on immune response was investigated by measuring the quantity and performance of circulating dendritic cells (DCs), a kind of immune cell, in wholesome volunteers. Twenty-one wholesome volunteers have been randomized to obtain placebo or AHCC for 4 weeks. The outcomes have been that the AHCC group had a considerably greater variety of whole DCs in comparison with after they first began the examine and in comparison with the management topics.

Different forms of immune cells have been additionally considerably elevated within the AHCC group in comparison with controls.9 For instance, AHCC promoted the exercise of pure killer (NK) cells in sufferers with most cancers. In animal fashions, it additionally protected in opposition to carbontetrachloride-induced liver harm, promoted wholesome blood glucose ranges and decreased apoptosis (i.e., programmed cell loss of life) of the thymus.10 AHCC is utilized by greater than 1,000 well being care amenities worldwide to scale back the incidence of infections in each wholesome and immune-compromised sufferers, enhance most cancers affected person outcomes, lower chemo side-effects, handle viral masses in hepatitis-C sufferers and assist these with liver illness—and naturally assist management HPV infections.11

AHCC & HPV

HPV is the most typical sexually transmitted an infection (STI) in the USA.12,13 Whereas there’s an HPV vaccine, which the Facilities for Illness Management and Prevention (CDC) recommends for all preteens, and everybody by way of age 26,14 the CDC additionally signifies that there’s no therapy for the virus itself—though there are therapies for the well being issues that HPV could cause.15 Nonetheless, AHCC has been proven to have effectiveness within the therapy of HPV.

Two pilot studies16 of 10 human sufferers every have been performed in girls with confirmed persistent excessive risk-HPV/HR-HPV infections. The primary examine evaluated AHCC 3 g/day from 5 weeks as much as six months, and the second examine evaluated AHCC 1 g/day for lower than eight months. Within the first human examine with 3 g/day AHCC, 4 of six (66.7 %) sufferers had confirmed HR-HPV clearance after three to 6 months. Within the second examine with 1 g/day AHCC, 4 of 9 (44 %) sufferers had confirmed HR-HPV clearance after seven months. The researchers concluded that these research demonstrated the effectiveness of AHCC in clearing HR-HPV infections.

Likewise, a subsequent randomized, double-blind, placebo-controlled study17 examined the efficacy, security and sturdiness of using AHCC supplementation for six months to help the host immune system for clearing HPV infections in 41 girls over 30 years of age with confirmed persistent HR-HPV infections for better than two years. Sufferers obtained placebo or AHCC 3-g supplementation by mouth as soon as every day on empty abdomen. The outcomes have been that 14 (63.6 %) of the 22 sufferers within the AHCC supplementation arm have been HPV unfavourable after six months, with 64.3 % (9/14) reaching an HPV unfavourable standing after they have been off supplementation for six months. On the placebo arm, two (10.5 %) of 19 sufferers had HPV unfavourable standing at 12 months. AHCC additionally improved immune markers. In conclusion, AHCC 3 g/day was efficient in supporting the host immune system to remove persistent HPV infections and was effectively tolerated, with no important opposed unwanted effects reported.

AHCC & COVID-19

Since COVID-19 wants no introduction, I’ll dive proper into it: In 2020, researchers wrote an article in a scientific journal, speculating that AHCC could also be helpful “within the prevention of ailments provoked by human pathogenic coronavirus, together with COVID-19.”18 Then, in April of 2022, different researchers printed an article in one other scientific journal, analyzing the effectiveness of AHCC in stopping and treating COVID-19 problems in mice. This study19 evaluated the consequences of the oral administration of AHCC on the host response to an infection by SARS-CoV-2 (the COVID-19 virus).

Oral administration of AHCC came about each different day for one week earlier than and in the future put up SARS-CoV-2 an infection. Outcomes have been that AHCC decreased the viral load and diminished irritation within the lungs. AHCC therapy additionally considerably diminished SARS-CoV-2-induced lethality within the mice. AHCC administration enhanced the enlargement of γδ T cells (i.e., necessary immune cells) within the spleen and lungs earlier than and after viral an infection and promoted T helper 1-prone mucosal and systemic T cell responses as effectively. In abstract, AHCC supplementation enhanced host resistance in opposition to delicate and extreme COVID-19 an infection primarily through the promotion of innate and adaptive T cell immune responses in mice.

AHCC & Lyme Illness

Lyme illness is probably the most reported vector-borne sickness (i.e., an infection transmitted to people and different animals by blood-feeding bugs, akin to mosquitoes, ticks and fleas) within the U.S. The illness is brought on by the bacterium Borrelia burgdorferi and is transmitted to people by way of the chunk of contaminated ticks. Typical signs embrace fever, headache, fatigue, a pores and skin rash and joint ache. If left untreated, an infection can unfold to the joints, coronary heart and nervous system, leading to irritation and long-term signs that embrace arthritis and/or intermittent ache in joints and muscle groups, facial palsy, cardiovascular abnormalities and cognitive disturbances. Latest analysis means that late-stage Lyme illness could also be a results of malfunctioning immune operate.

A pilot open-label examine was performed in 12 Lyme illness sufferers to judge the consequences of supplementation with 3 g of AHCC every day for eight weeks. Outcomes have been that after eight weeks of AHCC administration, AHCC ameliorated flu-like signs and manifestations within the eye, joint, muscle, nervous system and cardiovascular system. As well as, markers of irritation considerably decreased. In conclusion, this examine supplies preliminary proof that AHCC could also be efficient in treating sufferers with Lyme illness.

AHCC Security Analysis

To evaluate AHCC security, a examine was performed during which excessive doses (9 g) of AHCC got to wholesome topics. The outcomes have been that AHCC triggered no important abnormality in laboratory parameters, and the opposed results have been minimal with the excessive dose being tolerated by 85 % of the topics.20 Analysis has not demonstrated opposed results on the decrease doses usually used. Moreover, in a examine, AHCC was examined for potential drug interactions with chemotherapy brokers. The outcomes have been that AHCC does have the potential for drug-drug interactions involving chemotherapy brokers akin to doxorubicin or ondansetron, that are metabolized by the liver enzyme CYP450 2D6. Nonetheless, the general information counsel that AHCC could be secure to manage with most different chemotherapy brokers that aren’t metabolized through the CYP450 2D6 pathway.21

Confusion on Terminology Opens the Door to Faux Merchandise

Early analysis referenced that amongst different fractions, AHCC contained a posh of polysaccharides of a sure construction and referred to them utilizing a fabricated time period “Lively Hexose Correlated Compound.”22 The time period caught, creating confusion till researchers reverted to utilizing established chemical phrases to reference the completely different constituents of AHCC, akin to “alpha-1,4-glucans.”23 Sadly, faux merchandise looking for to capitalize on using the time period appeared in e-commerce, deceptive shoppers into considering they’re shopping for AHCC. This reality underscores the significance of buying merchandise from trusted sources who fastidiously display screen their assortment and choose real merchandise from respected manufacturers.

Conclusion

AHCC has demonstrated efficacy in selling immune operate and treating HPV an infection. Analysis in mice additionally means that it could be efficient in opposition to COVID-19. Moreover, preliminary analysis has proven constructive ends in using AHCC for treating Lyme illness. Extra analysis has likewise demonstrated the security of AHCC. To keep away from faux or adulterated supplies, it will be important make the most of AHCC merchandise with the registered trademark. VR

References

1 Jones Ok. Shiitake: The Therapeutic Mushroom. Rochester, VT: Therapeutic Arts Press, 1995.

2 Chang R. Practical properties of edible mushrooms. Nutr Rev 1996;54(11 Pt 2):S91-3.

3 Jones Ok. Shiitake” A significant medicinal mushroom. Alt Compl Ther 1998;4:53–9.

4 Taguchi I. Scientific efficacy of lentinan on sufferers with abdomen most cancers: Finish level outcomes of a four-year follow-up survey. Most cancers Detect Stop Suppl 1987;1:333–49.

5 Matsuoka H, Search engine optimization Y, Wakasugi H, et al. Lentinan potentiates immunity and prolongs survival time of some sufferers. Anticancer Res 1997;17:2751–6.

6 Ye SF, Ichimura Ok, Wakame Ok, Ohe M. Suppressive results of Lively Hexose Correlated Compound on the elevated exercise of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci 2003;74:593-602.

7 Kidd PM. The usage of mushroom glucans and proteoglycans in most cancers therapy. Altern Med Rev 2000;5(1):4-27. 8 Aviles H, O’Donnell P, Solar B, Sonnenfeld G. Lively hexose correlated compound (AHCC) enhances resistance to an infection in a mouse mannequin of surgical wound an infection. Surg Infect (Larchmt) 2006;7(6):527-35.

9 Terakawa N, Matsui Y, Satoi S, et al. Immunological impact of lively hexose correlated compound (AHCC) in wholesome volunteers: a double-blind, placebo-controlled trial. Nutr Most cancers 2008;60(5):643-51.

10 Ye SF, Ichimura Ok, Wakame Ok, Ohe M. Suppressive results of Lively Hexose Correlated Compound on the elevated exercise of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci 2003;74:593-602.

11 Research. AHCC® Affiliation. Retrieved August 2, 2022 from www.ahcc.internet/research/.

12 Genital HPV An infection – Primary Truth Sheet. Division of STD Prevention, Nationwide Middle for HIV, Viral Hepatitis, STD, and TB Prevention, Facilities for Illness Management and Prevention. Web page final reviewed: April 12, 2022. Retrieved August 2, 2022 from www.cdc.gov/std/hpv/stdfact-hpv.htm.Fu.

13 Cates JR, Wong T, Semenciw R, Creel L. Human Papillomavirus: A Hidden Epidemic in the USA. Inhabitants Reference Bureau. Might 1, 2001. Retrieved August 2, 2022 from www.prb.org/assets/human-papillomavirus-a-hidden-epidemic-in-the-united-states/#:~:textual content=Thepercent20humanpercent20papillomaviruspercent20ispercent20the,topercent20thepercent20Nationalpercent20Cancerpercent20Institute.

14 Genital HPV An infection – Primary Truth Sheet. Division of STD Prevention, Nationwide Middle for HIV, Viral Hepatitis, STD, and TB Prevention, Facilities for Illness Management and Prevention. Web page final reviewed: April 12, 2022. Retrieved August 2, 2022 from www.cdc.gov/std/hpv/stdfact-hpv.htm.Fu.

15 Human Papillomavirus (HPV) Therapy and Care. Division of STD Prevention, Nationwide Middle for HIV, Viral Hepatitis, STD, and TB Prevention, Facilities for Illness Management and Prevention. Web page final reviewed: July 22, 2021. Retrieved August 2, 2022 from www.cdc.gov/std/hpv/therapy.htm#:~:textual content=Therepercent20ispercent20nopercent20treatmentpercent20for,growpercent20inpercent20sizepercent20orpercent20number.

16 Smith JA, Mathew L, Gaikwad A, et al. From Bench to Bedside: Analysis of AHCC Supplementation to Modulate the Host Immunity to Clear Excessive-Danger Human Papillomavirus Infections. Entrance Oncol. 2019 Mar 20;9:173.

17 Smith JA, Gaikwad A, Mathew L, et al. AHCC ® Supplementation to Help Immune Perform to Clear Persistent Human Papillomavirus Infections. Entrance Oncol. 2022 Jun 22;12:881902.

18 Di Pierro F, Bertuccioli A, Cavecchia I. Attainable therapeutic position of a extremely standardized combination of lively compounds derived from cultured Lentinula edodes mycelia (AHCC) in sufferers contaminated with 2019 novel coronavirus. Minerva Gastroenterol Dietol. 2020 Jun;66(2):172-176.

19 Singh A, Adam A, Rodriguez L, Peng BH, Wang B, Xie X, Shi PY, Homma Ok, Wang T. Oral Supplementation with AHCC®, a Standardized Extract of Cultured Lentinula edodes Mycelia, Enhances Host Resistance in opposition to SARS-CoV-2 An infection. Pathogens. 2023 Apr 3;12(4):554.

20 Spierings EL, Fujii H, Solar B, Walshe T. A Section I examine of the security of the dietary complement, lively hexose correlated compound, AHCC, in wholesome volunteers. J Nutr Sci Vitaminol (Tokyo) 2007;53(6):536-9.

21 Mach CM, Fugii H, Wakame Ok, Smith J. Analysis of lively hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy brokers. J Soc Integr Oncol 2008;6(3):105-9.

22 Uno Ok, Chikumaru S, Hosokawa T, “Most cancers immunotherapy by a phyto-polysaccharide (AHCC): its results and technique,” AHCC Analysis Affiliation eighth Symposium, Sapporo, Japan, 2000.

23 Perez-Cantero A, Serrano D, Navarro-Rodriguez P, et al. Elevated Efficacy of Oral Fastened-Dose Mixture of Amphotericin B and AHCC® Pure Adjuvant in opposition to Aspergillosis. Pharmaceutics. 2019 Sep; 11(9): 456.

Gene Bruno, MS, MHS, the provost for Huntington College of Well being Sciences, is a nutritionist, herbalist, author and educator. For greater than 40 years he has educated and skilled pure product retailers and well being care professionals, has researched and formulated pure merchandise for dozens of dietary complement corporations, and has written articles on vitamin, natural drugs, nutraceuticals and integrative well being points for commerce, client magazines and peer-reviewed publications. He could be reached at gene.bruno@hchs.edu.

In October of 2022, Vitamin Retailer’s sister publication—Pure Practitioner—printed my article, “The Use of AHCC within the Therapy of Human Papillomavirus (HPV).” Within the present article, I’m additionally going to overview the worth of this nutraceutical for HPV, however as well as I’ll be discussing AHCC’s worth for immune operate, COVID-19 and Lyme illness as effectively. Let’s begin with a background overview of AHCC.

AHCC Background

Shiitake (Lentinula edodes) is a mushroom that has been used as a meals and conventional drugs for hundreds of years,1 and is at present used for selling wholesome immune operate,2 wholesome liver function3 and modulating the stomach4 and pancreas most cancers cells,5 and has been validated in scientific literature for these functions. This information was sufficiently promising to encourage one R&D centered nutraceutical firm in Japan to develop a novel shiitake-based compound referred to as AHCC, a singular cultured extract derived from the cell wall of the Shiitake mushroom mycelia, which is wealthy in a number of completely different polysaccharides, together with alpha-glucans and axoglucan fractions, in addition to amino acids, lipids and minerals. Oligosaccharides make up about 74 % of AHCC.6 AHCC is assumed to behave as a organic response modifier and is supported by greater than 30 human medical research and 50-plus papers in PubMed-indexed journals.

AHCC & Immune Perform

AHCC demonstrated early medical promise in selling wholesome immune response.7 This was proven in animal analysis the place AHCC helped restore immune response that had been negatively affected by trauma, an infection and meals deprivation.8 In people, the impact of AHCC on immune response was investigated by measuring the quantity and performance of circulating dendritic cells (DCs), a kind of immune cell, in wholesome volunteers. Twenty-one wholesome volunteers have been randomized to obtain placebo or AHCC for 4 weeks. The outcomes have been that the AHCC group had a considerably greater variety of whole DCs in comparison with after they first began the examine and in comparison with the management topics.

Different forms of immune cells have been additionally considerably elevated within the AHCC group in comparison with controls.9 For instance, AHCC promoted the exercise of pure killer (NK) cells in sufferers with most cancers. In animal fashions, it additionally protected in opposition to carbontetrachloride-induced liver harm, promoted wholesome blood glucose ranges and decreased apoptosis (i.e., programmed cell loss of life) of the thymus.10 AHCC is utilized by greater than 1,000 well being care amenities worldwide to scale back the incidence of infections in each wholesome and immune-compromised sufferers, enhance most cancers affected person outcomes, lower chemo side-effects, handle viral masses in hepatitis-C sufferers and assist these with liver illness—and naturally assist management HPV infections.11

AHCC & HPV

HPV is the most typical sexually transmitted an infection (STI) in the USA.12,13 Whereas there’s an HPV vaccine, which the Facilities for Illness Management and Prevention (CDC) recommends for all preteens, and everybody by way of age 26,14 the CDC additionally signifies that there’s no therapy for the virus itself—though there are therapies for the well being issues that HPV could cause.15 Nonetheless, AHCC has been proven to have effectiveness within the therapy of HPV.

Two pilot studies16 of 10 human sufferers every have been performed in girls with confirmed persistent excessive risk-HPV/HR-HPV infections. The primary examine evaluated AHCC 3 g/day from 5 weeks as much as six months, and the second examine evaluated AHCC 1 g/day for lower than eight months. Within the first human examine with 3 g/day AHCC, 4 of six (66.7 %) sufferers had confirmed HR-HPV clearance after three to 6 months. Within the second examine with 1 g/day AHCC, 4 of 9 (44 %) sufferers had confirmed HR-HPV clearance after seven months. The researchers concluded that these research demonstrated the effectiveness of AHCC in clearing HR-HPV infections.

Likewise, a subsequent randomized, double-blind, placebo-controlled study17 examined the efficacy, security and sturdiness of using AHCC supplementation for six months to help the host immune system for clearing HPV infections in 41 girls over 30 years of age with confirmed persistent HR-HPV infections for better than two years. Sufferers obtained placebo or AHCC 3-g supplementation by mouth as soon as every day on empty abdomen. The outcomes have been that 14 (63.6 %) of the 22 sufferers within the AHCC supplementation arm have been HPV unfavourable after six months, with 64.3 % (9/14) reaching an HPV unfavourable standing after they have been off supplementation for six months. On the placebo arm, two (10.5 %) of 19 sufferers had HPV unfavourable standing at 12 months. AHCC additionally improved immune markers. In conclusion, AHCC 3 g/day was efficient in supporting the host immune system to remove persistent HPV infections and was effectively tolerated, with no important opposed unwanted effects reported.

AHCC & COVID-19

Since COVID-19 wants no introduction, I’ll dive proper into it: In 2020, researchers wrote an article in a scientific journal, speculating that AHCC could also be helpful “within the prevention of ailments provoked by human pathogenic coronavirus, together with COVID-19.”18 Then, in April of 2022, different researchers printed an article in one other scientific journal, analyzing the effectiveness of AHCC in stopping and treating COVID-19 problems in mice. This study19 evaluated the consequences of the oral administration of AHCC on the host response to an infection by SARS-CoV-2 (the COVID-19 virus).

Oral administration of AHCC came about each different day for one week earlier than and in the future put up SARS-CoV-2 an infection. Outcomes have been that AHCC decreased the viral load and diminished irritation within the lungs. AHCC therapy additionally considerably diminished SARS-CoV-2-induced lethality within the mice. AHCC administration enhanced the enlargement of γδ T cells (i.e., necessary immune cells) within the spleen and lungs earlier than and after viral an infection and promoted T helper 1-prone mucosal and systemic T cell responses as effectively. In abstract, AHCC supplementation enhanced host resistance in opposition to delicate and extreme COVID-19 an infection primarily through the promotion of innate and adaptive T cell immune responses in mice.

AHCC & Lyme Illness

Lyme illness is probably the most reported vector-borne sickness (i.e., an infection transmitted to people and different animals by blood-feeding bugs, akin to mosquitoes, ticks and fleas) within the U.S. The illness is brought on by the bacterium Borrelia burgdorferi and is transmitted to people by way of the chunk of contaminated ticks. Typical signs embrace fever, headache, fatigue, a pores and skin rash and joint ache. If left untreated, an infection can unfold to the joints, coronary heart and nervous system, leading to irritation and long-term signs that embrace arthritis and/or intermittent ache in joints and muscle groups, facial palsy, cardiovascular abnormalities and cognitive disturbances. Latest analysis means that late-stage Lyme illness could also be a results of malfunctioning immune operate.

A pilot open-label examine was performed in 12 Lyme illness sufferers to judge the consequences of supplementation with 3 g of AHCC every day for eight weeks. Outcomes have been that after eight weeks of AHCC administration, AHCC ameliorated flu-like signs and manifestations within the eye, joint, muscle, nervous system and cardiovascular system. As well as, markers of irritation considerably decreased. In conclusion, this examine supplies preliminary proof that AHCC could also be efficient in treating sufferers with Lyme illness.

AHCC Security Analysis

To evaluate AHCC security, a examine was performed during which excessive doses (9 g) of AHCC got to wholesome topics. The outcomes have been that AHCC triggered no important abnormality in laboratory parameters, and the opposed results have been minimal with the excessive dose being tolerated by 85 % of the topics.20 Analysis has not demonstrated opposed results on the decrease doses usually used. Moreover, in a examine, AHCC was examined for potential drug interactions with chemotherapy brokers. The outcomes have been that AHCC does have the potential for drug-drug interactions involving chemotherapy brokers akin to doxorubicin or ondansetron, that are metabolized by the liver enzyme CYP450 2D6. Nonetheless, the general information counsel that AHCC could be secure to manage with most different chemotherapy brokers that aren’t metabolized through the CYP450 2D6 pathway.21

Confusion on Terminology Opens the Door to Faux Merchandise

Early analysis referenced that amongst different fractions, AHCC contained a posh of polysaccharides of a sure construction and referred to them utilizing a fabricated time period “Lively Hexose Correlated Compound.”22 The time period caught, creating confusion till researchers reverted to utilizing established chemical phrases to reference the completely different constituents of AHCC, akin to “alpha-1,4-glucans.”23 Sadly, faux merchandise looking for to capitalize on using the time period appeared in e-commerce, deceptive shoppers into considering they’re shopping for AHCC. This reality underscores the significance of buying merchandise from trusted sources who fastidiously display screen their assortment and choose real merchandise from respected manufacturers.

Conclusion

AHCC has demonstrated efficacy in selling immune operate and treating HPV an infection. Analysis in mice additionally means that it could be efficient in opposition to COVID-19. Moreover, preliminary analysis has proven constructive ends in using AHCC for treating Lyme illness. Extra analysis has likewise demonstrated the security of AHCC. To keep away from faux or adulterated supplies, it will be important make the most of AHCC merchandise with the registered trademark. VR

References

1 Jones Ok. Shiitake: The Therapeutic Mushroom. Rochester, VT: Therapeutic Arts Press, 1995.

2 Chang R. Practical properties of edible mushrooms. Nutr Rev 1996;54(11 Pt 2):S91-3.

3 Jones Ok. Shiitake” A significant medicinal mushroom. Alt Compl Ther 1998;4:53–9.

4 Taguchi I. Scientific efficacy of lentinan on sufferers with abdomen most cancers: Finish level outcomes of a four-year follow-up survey. Most cancers Detect Stop Suppl 1987;1:333–49.

5 Matsuoka H, Search engine optimization Y, Wakasugi H, et al. Lentinan potentiates immunity and prolongs survival time of some sufferers. Anticancer Res 1997;17:2751–6.

6 Ye SF, Ichimura Ok, Wakame Ok, Ohe M. Suppressive results of Lively Hexose Correlated Compound on the elevated exercise of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci 2003;74:593-602.

7 Kidd PM. The usage of mushroom glucans and proteoglycans in most cancers therapy. Altern Med Rev 2000;5(1):4-27. 8 Aviles H, O’Donnell P, Solar B, Sonnenfeld G. Lively hexose correlated compound (AHCC) enhances resistance to an infection in a mouse mannequin of surgical wound an infection. Surg Infect (Larchmt) 2006;7(6):527-35.

9 Terakawa N, Matsui Y, Satoi S, et al. Immunological impact of lively hexose correlated compound (AHCC) in wholesome volunteers: a double-blind, placebo-controlled trial. Nutr Most cancers 2008;60(5):643-51.

10 Ye SF, Ichimura Ok, Wakame Ok, Ohe M. Suppressive results of Lively Hexose Correlated Compound on the elevated exercise of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci 2003;74:593-602.

11 Research. AHCC® Affiliation. Retrieved August 2, 2022 from www.ahcc.internet/research/.

12 Genital HPV An infection – Primary Truth Sheet. Division of STD Prevention, Nationwide Middle for HIV, Viral Hepatitis, STD, and TB Prevention, Facilities for Illness Management and Prevention. Web page final reviewed: April 12, 2022. Retrieved August 2, 2022 from www.cdc.gov/std/hpv/stdfact-hpv.htm.Fu.

13 Cates JR, Wong T, Semenciw R, Creel L. Human Papillomavirus: A Hidden Epidemic in the USA. Inhabitants Reference Bureau. Might 1, 2001. Retrieved August 2, 2022 from www.prb.org/assets/human-papillomavirus-a-hidden-epidemic-in-the-united-states/#:~:textual content=Thepercent20humanpercent20papillomaviruspercent20ispercent20the,topercent20thepercent20Nationalpercent20Cancerpercent20Institute.

14 Genital HPV An infection – Primary Truth Sheet. Division of STD Prevention, Nationwide Middle for HIV, Viral Hepatitis, STD, and TB Prevention, Facilities for Illness Management and Prevention. Web page final reviewed: April 12, 2022. Retrieved August 2, 2022 from www.cdc.gov/std/hpv/stdfact-hpv.htm.Fu.

15 Human Papillomavirus (HPV) Therapy and Care. Division of STD Prevention, Nationwide Middle for HIV, Viral Hepatitis, STD, and TB Prevention, Facilities for Illness Management and Prevention. Web page final reviewed: July 22, 2021. Retrieved August 2, 2022 from www.cdc.gov/std/hpv/therapy.htm#:~:textual content=Therepercent20ispercent20nopercent20treatmentpercent20for,growpercent20inpercent20sizepercent20orpercent20number.

16 Smith JA, Mathew L, Gaikwad A, et al. From Bench to Bedside: Analysis of AHCC Supplementation to Modulate the Host Immunity to Clear Excessive-Danger Human Papillomavirus Infections. Entrance Oncol. 2019 Mar 20;9:173.

17 Smith JA, Gaikwad A, Mathew L, et al. AHCC ® Supplementation to Help Immune Perform to Clear Persistent Human Papillomavirus Infections. Entrance Oncol. 2022 Jun 22;12:881902.

18 Di Pierro F, Bertuccioli A, Cavecchia I. Attainable therapeutic position of a extremely standardized combination of lively compounds derived from cultured Lentinula edodes mycelia (AHCC) in sufferers contaminated with 2019 novel coronavirus. Minerva Gastroenterol Dietol. 2020 Jun;66(2):172-176.

19 Singh A, Adam A, Rodriguez L, Peng BH, Wang B, Xie X, Shi PY, Homma Ok, Wang T. Oral Supplementation with AHCC®, a Standardized Extract of Cultured Lentinula edodes Mycelia, Enhances Host Resistance in opposition to SARS-CoV-2 An infection. Pathogens. 2023 Apr 3;12(4):554.

20 Spierings EL, Fujii H, Solar B, Walshe T. A Section I examine of the security of the dietary complement, lively hexose correlated compound, AHCC, in wholesome volunteers. J Nutr Sci Vitaminol (Tokyo) 2007;53(6):536-9.

21 Mach CM, Fugii H, Wakame Ok, Smith J. Analysis of lively hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy brokers. J Soc Integr Oncol 2008;6(3):105-9.

22 Uno Ok, Chikumaru S, Hosokawa T, “Most cancers immunotherapy by a phyto-polysaccharide (AHCC): its results and technique,” AHCC Analysis Affiliation eighth Symposium, Sapporo, Japan, 2000.

23 Perez-Cantero A, Serrano D, Navarro-Rodriguez P, et al. Elevated Efficacy of Oral Fastened-Dose Mixture of Amphotericin B and AHCC® Pure Adjuvant in opposition to Aspergillosis. Pharmaceutics. 2019 Sep; 11(9): 456.

Gene Bruno, MS, MHS, the provost for Huntington College of Well being Sciences, is a nutritionist, herbalist, author and educator. For greater than 40 years he has educated and skilled pure product retailers and well being care professionals, has researched and formulated pure merchandise for dozens of dietary complement corporations, and has written articles on vitamin, natural drugs, nutraceuticals and integrative well being points for commerce, client magazines and peer-reviewed publications. He could be reached at gene.bruno@hchs.edu.





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