Can Stem Cell Remedy Enhance Testosterone? – T Nation Content material – COMMUNITY


A Promising New Research

Will stem cell remedy change testosterone alternative remedy? A brand new examine investigates.

Stem cell remedy might someday be used to restore your broken coronary heart, possibly even develop a model new one for you. It might remedy Parkinson’s and Alzheimer’s, restore spinal wire accidents, heal the blind, regenerate broken or ageing tissues, and battle off most cancers. Proper now, nevertheless, stem cell remedy remains to be within the experimental levels.

So, might stem cell remedy be used to spice up testosterone? If stem cells might restore the perform of the hypothalamus, or the pituitary and Leydig cells of the testicles, it might improve endogenous testosterone manufacturing.

This could be probably the most supreme strategy to restore T ranges in males. It will keep away from the potential disadvantages of exogenous testosterone administration, and even the usage of different brokers that improve testosterone manufacturing, like gonadotropic hormones and anti-estrogens.

A Current Research

A brand new examine used multipotent mesenchymal stromal cells or MMSCs (1). These cells will be obtained from a wide range of sources (bone marrow, adipose tissue, or umbilical wire blood) and may differentiate into a number of varieties of cells. They’re additionally self-replicating with out inflicting your immune system to kick in and think about them as a menace.

On this examine, 60 males with non-obstructive azoospermia or NOA (males with no sperm, brought on by one thing apart from a blockage) got MMSCs derived from donated, post-birth umbilical wire blood. It was injected each intravenously and, yep, proper into the testicles.

Testosterone and gonadotropins (LH and FSH) have been measured at baseline and three months after the process. Common complete testosterone ranges went from being within the hypogonadal vary – round 251 ng/dl – into the traditional vary, round 355 ng/dl. LH additionally rose whereas FSH, oddly sufficient, declined.

The researchers couldn’t clarify the discrepancy between the rise of LH and the lower in FSH, nor precisely how testosterone ranges rose. Presumably, at the least a part of the rise was brought on by newly differentiated Leydig cells.

Whereas the info clearly present that testosterone rose on common, a good portion of the lads nonetheless couldn’t get out of the hypogonadal vary. Clearly, we’d like extra analysis to see how efficient stem cell remedy might be as a technique for restoring testosterone manufacturing.

Infertile males with NOA is probably not very consultant of somebody experiencing low T resulting from ageing or different causes. Nonetheless, these are promising outcomes. It is tantalizing to suppose that someday, low T is likely to be handled with a number of periodic injections of stem cells.

After all, stem cell remedy is also used for doping in sports activities. This could be tough to detect with commonplace approaches. Umbilical wire blood is likely to be detectable by way of DNA variations, however what about these derived from your individual adipose tissue? Difficult, difficult…

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Reference

  1. A Popova, T Shatylko, S Gamidov, D Silachev, G Sukhikh, (106) Stem Cell Remedy Results in an Improve in Testosterone Ranges in Infertile Males, The Journal of Sexual Medication, Quantity 21, Difficulty Supplement_2, March 2024, qdae002.096, https://doi.org/10.1093/jsxmed/qdae002.096



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